Acoustic reflex patterns in amyotrophic lateral sclerosis

Stapedial reflex in amyotrophic lateral sclerosis.

OBJECTIVE To examine mechanisms controlling the stapedial reflex in patients with amyotrophic sclerosis (ALS). METHODS The stapedial reflex was examined using impedance audiometry in 38 patients with sporadic ALS and in 25 age matched controls. RESULTS All patients showed normal reflex decay test results. There were no significant differences between patients with ALS and control subjects i...

Application of acoustic speech analysis in amyotrophic lateral sclerosis subjects

Tongue movements and their acoustic consequences in amyotrophic lateral sclerosis.

OBJECTIVE The relations between acoustic measures and their articulatory bases have rarely been tested in dysarthria but are important for diagnostic and treatment purposes. We tested the association between acoustic measures of F2 range and F2 slope with kinematic measures of tongue movement displacement and speed in individuals with amyotrophic lateral sclerosis (ALS) and healthy controls spe...

Amyotrophic Lateral Sclerosis in a Patient with Behçet’s ‎Disease

Behçet’s ‎disease is a multisystem vasculitis. Its neurological involvement mostly includes parenchymal and non-parenchymal central nervous system manifestations. Peripheral nervous system presentations are rare. A 32-yr-old male patient who fulfilled the international study group criteria for Behçet’s disease, referred to our center with walking difficulty and repeated falling downs. Neurologi...

Differential histone deacetylase mRNA expression patterns in amyotrophic lateral sclerosis.

Histone deacetylases (HDACs) are important regulators of gene expression and cell differentiation. The HDAC inhibitors have recently been considered as potential novel neuroprotective drugs for the treatment of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). A major limitation, however, lies in the broad spectrum of action of currently available HDAC inhibitors that may ...